Study on Fe3O4 Magnetic Nanoparticles ‎Size Effect on Temperature Distribution ‎of Tumor in Hyperthermia: A Finite ‎Element Method ‎

   In recent years, Hyperthermia has been used as an emerging technique for cancer treatment, especially for localized tumors. One of the promising cancer treatment approaches is magnetic nanoparticle (MNPs) Hyperthermia. In this theoretical work, the temperature distribution of a common tumor over the different sizes of Fe3O4 magnetic nanoparticles, namely 25, 50, 100, and 200 nm, was studied via the finite element method. A two-dimensional method was used to simulate the tumor tissue, in which nanoparticles were incorporated and dispersed into the tumor uniformly. The bio heat transfer equation (BHTE) was applied to calculate the thermal processes in the human body. Results elucidated that decreasing magnetic nanoparticle size caused more temperature rise in the tumor cell during the Hyperthermia treatment, which led to better performance of the treatment. Finally, simulation results showed that the Fe3O4 magnetic nanoparticles with the sizes of 50-100 nm were applicable for Hyperthermia therapy with the optimum cellular uptake.